Informing etiologic research priorities for squamous cell esophageal cancer in Africa: A review of setting-specific exposures to known and putative risk factors.

McCormack, V A and Menya, D and Munishi, M O and Dzamalala, C and Gasmelseed, N and Leon Roux, M and Assefa, M and Osano, O and Watts, M and Mwasamwaja, A O and Mmbaga, B T and Murphy, G and Abnet, C C and Dawsey, S M and Schüz, J (2017) Informing etiologic research priorities for squamous cell esophageal cancer in Africa: A review of setting-specific exposures to known and putative risk factors. International journal of cancer, 140 (2). pp. 259-271. ISSN 1097-0215

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Abstract

Esophageal squamous cell carcinoma (ESCC) is one of the most common cancers in most Eastern and Southern African countries, but its etiology has been understudied to date. To inform its research agenda, we undertook a review to identify, of the ESCC risk factors which have been established or strongly suggested worldwide, those with a high prevalence or high exposure levels in any ESCC-affected African setting and the sources thereof. We found that for almost all ESCC risk factors known to date, including tobacco, alcohol, hot beverage consumption, nitrosamines and both inhaled and ingested PAHs, there is evidence of population groups with raised exposures, the sources of which vary greatly between cultures across the ESCC corridor. Research encompassing these risk factors is warranted and is likely to identify primary prevention strategies.

Item Type: Article
Subjects: R Medicine > RB Pathology
Depositing User: Moneeb Hassan
Date Deposited: 10 Jan 2018 05:12
Last Modified: 10 Jan 2018 05:12
URI: http://search.srh.edu.sd/id/eprint/3301

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