Association of Plasma Ghrelin Levels with Insulin Resistance in Type 2 Diabetes Mellitus among Saudi Subjects.

Al Qarni, Ali Ahmed and Joatar, Faris Elbahi and Das, Nagalla and Awad, Mohamed and Eltayeb, Mona and Al-Zubair, Ahmed Gasim and Ali, Muhalab E and Al Masaud, Abdulaziz and Shire, Abdirashid M and Gumaa, Khalid and Giha, Hayder A (2017) Association of Plasma Ghrelin Levels with Insulin Resistance in Type 2 Diabetes Mellitus among Saudi Subjects. Endocrinology and metabolism (Seoul, Korea), 32 (2). pp. 230-240. ISSN 2093-596X

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BACKGROUND Although the exact mechanism of insulin resistance (IR) has not yet been established, IR is the hallmark characteristic of type 2 diabetes mellitus (T2DM). The aim of this study was to examine the relationship between plasma ghrelin levels and IR in Saudi subjects with T2DM. METHODS Patients with T2DM (n=107, cases) and non-diabetic apparently healthy subjects (n=101, controls) from Saudi Arabia were included in this study. The biochemical profiles and plasma insulin levels of all subjects were analyzed, and IR was estimated using the homeostatic model assessment of insulin resistance (HOMA-IR) index. Active ghrelin levels in plasma were measured using the radioimmunoassay technique. RESULTS Only 46.7% (50 of 107) of the T2DM subjects had IR, including 26% (28 of 107) with severe IR (HOMA-IR ≥5), while 5.9% (six of 101) of the controls had moderate IR (3 ≤HOMA-IR <5). HOMA-IR values were not associated with age, disease duration, or gender. Importantly, T2DM itself and the co-occurrence of IR with T2DM were significantly associated with low plasma ghrelin levels. However, ghrelin levels were inversely correlated with the HOMA-IR index, body weight, and fasting plasma insulin levels, mainly in the control subjects, which was indicative of the breakdown of metabolic homeostasis in T2DM. CONCLUSION The prevalence of IR was relatively low, and IR may be inversely associated with plasma ghrelin levels among Saudi patients with T2DM.

Item Type: Article
Subjects: R Medicine > RC Internal medicine
Divisions: University of Khartoum > Faculty of Medicine, Health and Life Sciences > Department of Biological Sciences
Depositing User: Unnamed user with email
Date Deposited: 23 Jul 2018 18:03
Last Modified: 23 Jul 2018 18:03

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