DNMT1 is predictive of survival and associated with Ki-67 expression in R-CHOP-treated diffuse large B-cell lymphomas.

Loo, Suet Kee and Ch'ng, Ewe Seng and Lawrie, Charles H and Muruzabal, María Arestin and Gaafar, Ayman and Pomposo, María Puente and Husin, Azlan and Md Salleh, Md Salzihan and Banham, Alison H and Pedersen, Lars M and Møller, Michael B and Green, Tina M and Wong, Kah Keng (2017) DNMT1 is predictive of survival and associated with Ki-67 expression in R-CHOP-treated diffuse large B-cell lymphomas. Pathology, 49 (7). pp. 731-739. ISSN 1465-3931

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Abstract

DNMT1 is a target of approved anti-cancer drugs including decitabine. However, the prognostic value of DNMT1 protein expression in R-CHOP-treated diffuse large B-cell lymphomas (DLBCLs) remains unexplored. Here we showed that DNMT1 was expressed in the majority of DLBCL cases (n = 209/230, 90.9%) with higher expression in germinal centre B-cell-like (GCB)-DLBCL subtype. Low and negative DNMT1 expression (20% cut-off, n = 33/230, 14.3%) was predictive of worse overall survival (OS; p < 0.001) and progression-free survival (PFS; p < 0.001). Nonetheless, of the 209 DNMT1 positive patients, 33% and 42% did not achieve 5-year OS and PFS, respectively, indicating that DNMT1 positive patients showed considerably heterogeneous outcomes. Moreover, DNMT1 was frequently expressed in mitotic cells and significantly correlated with Ki-67 or BCL6 expression (r = 0.60 or 0.44, respectively; p < 0.001). We demonstrate that DNMT1 is predictive of DLBCL patients' survival, and suggest that DNMT1 could be a DLBCL therapeutic target due to its significant association with Ki-67.

Item Type: Article
Subjects: Q Science > QR Microbiology > QR180 Immunology
Divisions: University of Khartoum > Faculty of Medicine, Health and Life Sciences > Department of Biological Sciences
Depositing User: Unnamed user with email almegdadsharaf@gmail.com
Date Deposited: 26 Jul 2018 16:35
Last Modified: 26 Jul 2018 16:35
URI: http://search.srh.edu.sd/id/eprint/4917

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