Diversity of Middle East respiratory syndrome coronaviruses in 109 dromedary camels based on full-genome sequencing, Abu Dhabi, United Arab Emirates.

Yusof, Mohammed Farouk and Queen, Krista and Eltahir, Yassir Mohammed and Paden, Clinton R and Al Hammadi, Zulaikha Mohamed Abdel Hameed and Tao, Ying and Li, Yan and Khalafalla, Abdelmalik Ibrahim and Shi, Mang and Zhang, Jing and Mohamed, Muzammil Sayed Ahmed Elhaj and Abd Elaal Ahmed, Mahmud Hamed and Azeez, Ihsaan Abdulwahab and Bensalah, Oum Keltoum and Eldahab, Ziyada Swar and Al Hosani, Farida Ismail and Gerber, Susan I and Hall, Aron J and Tong, Suxiang and Al Muhairi, Salama Suhail (2017) Diversity of Middle East respiratory syndrome coronaviruses in 109 dromedary camels based on full-genome sequencing, Abu Dhabi, United Arab Emirates. Emerging microbes & infections, 6 (11). e101. ISSN 2222-1751

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Abstract

Middle East respiratory syndrome coronavirus (MERS-CoV) was identified on the Arabian Peninsula in 2012 and is still causing cases and outbreaks in the Middle East. When MERS-CoV was first identified, the closest related virus was in bats; however, it has since been recognized that dromedary camels serve as a virus reservoir and potential source for human infections. A total of 376 camels were screened for MERS-Cov at a live animal market in the Eastern Region of the Emirate of Abu Dhabi, UAE. In all, 109 MERS-CoV-positive camels were detected in week 1, and a subset of positive camels were sampled again weeks 3 through 6. A total of 126 full and 3 nearly full genomes were obtained from 139 samples. Spike gene sequences were obtained from 5 of the 10 remaining samples. The camel MERS-CoV genomes from this study represent 3 known and 2 potentially new lineages within clade B. Within lineages, diversity of camel and human MERS-CoV sequences are intermixed. We identified sequences from market camels nearly identical to the previously reported 2015 German case who visited the market during his incubation period. We described 10 recombination events in the camel samples. The most frequent recombination breakpoint was the junctions between ORF1b and S. Evidence suggests MERS-CoV infection in humans results from continued introductions of distinct MERS-CoV lineages from camels. This hypothesis is supported by the camel MERS-CoV genomes sequenced in this study. Our study expands the known repertoire of camel MERS-CoVs circulating on the Arabian Peninsula.

Item Type: Article
Subjects: Q Science > QL Zoology
Divisions: University of Khartoum > Faculty of Science > Department of Biology
Depositing User: Unnamed user with email almegdadsharaf@gmail.com
Date Deposited: 31 Jul 2018 11:49
Last Modified: 31 Jul 2018 11:49
URI: http://search.srh.edu.sd/id/eprint/4973

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